--- title: HPE ProLiant Compute Powered by AMD EPYC™ Processors description: HPE ProLiant Compute powered by AMD EPYC™ processors helps organizations modernize infrastructure, optimize workloads, improve efficiency, and support next-generation demands from AI to VDI. image: https://hubspot.dhecs.com/hubfs/Imported_Blog_Media/HPE-ProLiant-Compute-Powered-by-AMD-EPYC-Processors-2.webp --- [Skip to content](https://hubspot.dhecs.com/blog/hpe-proliant-compute-amd-epyc-workload-optimization#main-content) [(303) 290-6050](tel:+13032906050) | [Toll Free: (888) 290-6050](tel:+18882906050) | [sales@dhecs.com](mailto:sales@dhecs.com) [![DHE Computer Systems](https://www.dhecs.com/wp-content/uploads/2025/03/dhe-logo-wordmark-color-400w.webp)](https://www.dhecs.com) - Solutions Core [AI](https://www.dhecs.com/solutions/ai-solutions/) [Cloud](https://www.dhecs.com/solutions/cloud-solutions/) [Data Center](https://www.dhecs.com/solutions/data-center-solutions/) 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[Client Testimonials](https://www.dhecs.com/#dhereviews) [DHE Insights](https://hubspot.dhecs.com/blog/) [Support](https://www.dhecs.com/#support) [Schedule a Call](https://www.dhecs.com/contact-us/#contactusform) [DHE Store](https://myshop.dhecs.store/) [(303) 290-6050](tel:+13032906050) [Toll Free: (888) 290-6050](tel:+18882906050) [sales@dhecs.com](mailto:sales@dhecs.com) On This Page [‹ All Blog Posts](https://hubspot.dhecs.com/blog) # HPE ProLiant Compute Powered by AMD EPYC™ Processors Jun 23, 2026, 7:30:08 AM • Reading time Cloud & Data Center, Technology & Innovation, data center modernization, AI infrastructure, edge AI, AMD EPYC On This Page ![\ ## Optimize Every Workload with HPE ProLiant Compute Powered by AMD EPYC™ Processors IT environments are growing increasingly complex as organizations extend their workers and resources across multiple clouds and edges. The ability to harness data and workloads across every type of environment is key to understanding their customers and processes, so organizations can make decisions faster to achieve better business results. With the pressure to deploy AI applications and rethink virtualization strategies, IT needs advanced capabilities to maximize productivity and performance. ## HPE ProLiant Compute for Modern Workloads HPE can help achieve performance and efficiency optimization for every workload, from AI to VDI. HPE ProLiant Compute powered by the latest AMD EPYC™ processors brings a new level of security, optimized performance, liquid cooling, and productivity to IT operations. With the addition of new Gen12 servers, the HPE ProLiant Compute portfolio delivers modern hardware and software platforms for today’s computing challenges and next gen workloads. These comprehensive solutions help to make every environment optimized, automated, and secure: - **DL145 Gen11:** Edge AI - **DL325 Gen11:** Software-defined compute - **DL345 Gen11:** SDS and CDN - **DL365 Gen11:** EDA and VDI - **DL385 Gen11:** AI, ML, and big data analytics - **DL325 Gen12:** Hybrid cloud and container - **DL345 Gen12:** Virtualization and SDS Whether you need more compute, memory, density, storage, or all these capabilities combined, HPE and AMD can deliver a modern solution tailored to your specific workloads. ## Partnership Value ### Leveraging Out-of-the-Box Performance HPE ProLiant Compute Gen11 and Gen12 servers deliver out-of-the-box performance to help you gain immediate ROI. Optimized for diverse, data-intensive workloads from Day 1, these platforms hold numerous world records in performance and efficiency. ### Discovering the Latest Solutions Gen12 servers build on on the legacy of HPE ProLiant Compute. Platforms feature new 5th Gen AMD EPYC CPUs, HPE iLO 7 embedded management technology, superior memory capacity, and increased energy efficiency to accelerate innovation. ### Automating Enterprise Environments AMD-based HPE servers are easily deployable and readily accessible to help accelerate transformation. Competitive platforms often force organizations to adopt new instruction sets, recompile new binaries, or add software. HPE ProLiant Compute makes automation part of innovation, delivering single management solutions. ### Optimizing Your IT HPE ProLiant Compute delivers a new level of performance and efficiency with the economics to optimize hybrid environments and power workloads from VDI to AI. Reign in data center sprawl with up to 2:1 server consolidation, freeing up space and resources. You can also adopt a consumption-based cloud model through HPE GreenLake. ### Delivering Industry-Leading Cooling Technology HPE is a leader in liquid cooling innovation. Our pursuit of greater, more sustainable performance has lead to direct liquid cooling technology that is shaping the future of computing, from enterprise scale to the world’s largest machines. ### Unlocking Next-Level Security HPE trusted security by design is an edge-to-cloud security architecture that offers multi-layered protection at rack and server levels. HPE ProLiant Compute servers feature a robust, security-first design built through a trusted supply chain that helps to defend environments against current and future threats. ## Customer Benefits - Expand your AI initiatives and unlock more value from data - Optimize performance of hybrid environments - Accelerate innovation everywhere data lives - Increase operational efficiency with optimized infrastructure and liquid cooling - Achieve superior economics with cloud services ## Key Takeaways - Industry-leading performance and energy efficiency - Optimized performance for every workload - Sustainable solutions for your hybrid world - Trusted security by design - Intuitive cloud operating experience ## Learn More Explore HPE ProLiant Compute solutions and discover how HPE and AMD can help modernize your infrastructure for AI, VDI, hybrid cloud, virtualization, and next-generation workloads. 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